Are cyclooxygenase-2-selective inhibitors safe for the kidneys?

Olivier Phan, Pascal Meier and Michel Burnier

Joint Bone Spine

2003, Vol 7, issue 4, pages 237-241.

An editorial in Joint Bone Spine has questioned the safety to the kidneys of the new generation of anti-inflammatory medications. The latest non-steroidal anti-inflammatory drugs (NSAIDs) are known as COX 2 inhibitors and their use has been advocated on the basis that they cause fewer side effects to the stomach and kidneys. Although there is evidence that COX-2 inhibitors reduce gastro-intestinal side effects, there is no such proof that these drugs are totally safe for the kidneys.

As with all medications, NSAIDs can have toxic effects on the kidneys. These effects can cause acute kidney failure, water retention, inflammation of the kidney or increased blood pressure. Usually, this is because they have the effect of decreasing blood flow to the kidney and filtration within it. Minor problems can be resolved by simply discontinuing the medication.

Although these conditions can affect anyone, certain people are more susceptible; older people, those with pre-existing kidney problems, diabetics, and those with cardiac problems. Phan et al conclude that COX 2 inhibitors have a similar degree of kidney toxicity to other NSAIDs and advocate physicians identifying high risk patients as the most effective way to prevent side effects. They also advocate using the lowest possible dosage for the shortest possible time.

Phan et al list the risk factors for renal toxicity of NSAIDs:

Go to the journal >

< top of page


SHOP
Shopping Basket

0 Items
£0.00



Pounds Euros US Dollars
Search Products
Browse Products
Supports & Braces Hot & Cold Therapy Foot Care Exercise & Rehabilitation Back & Neck Care Taping & Strapping First Aid Kits & Supplies Performance & Recovery Running Accessories
Help